Chloroquine effective against Coronavirus

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UPDATED: Trump Says FDA Approved Anti-Malaria Drug Chloroquine To Test As Coronavirus Treatment

Topline: President Trump said in a Thursday press briefing that chloroquine, a drug used to treat malaria and severe arthritis, was approved by the Food and Drug Administration to test as a COVID-19 coronavirus treatment, as the number of cases nationwide continues to increase.

  • The drug will be used in a clinical trial, according to FDA commissioner Dr. Stephen Hahn, who spoke during the press briefing.
  • Trump also said that other anti-viral medications will be fast-tracked for FDA approval.
  • “We will collect that data and make the absolute right decisions based upon those data about the safety and efficacy of the treatments,” said Hahn.
  • Trump also claimed that the White House has “slashed red tape” to speed up approval for vaccines and other treatments.
  • Trump added that the FDA approved “compassionate use” for a number of patients, which allows very ill patients to use drugs not yet approved by the agency for widespread use.

The anti-malaria drug is available and cheap. Democrats and their Trump-hating fearmongering media are not going to be happy.

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Delingpole: Studies Claim Malaria Drug Chloroquine Effective Against Coronavirus

By James Delingpole,  Breitbart, March 18, 2020:

Sure this Coronavirus pandemic is a misery but I’m much more optimistic than most at the moment. Here’s one of the reasons: there’s an effective treatment already and it’s available and cheap, according to studies.

Chloroquine phosphate, an old-fashioned anti-malarial drug, has shown strong results against COVID-19 infections in South Korea and China.

Here is one, by James M Todaro and Gregory J Rigano, in association with Stanford University School of Medicine and National Academy of Sciences Researchers.

According to the summary:

Recent guidelines from South Korea and China report that chloroquine is an effective antiviral therapeutic treatment against Coronavirus Disease 2019.  Use of chloroquine (tablets) is showing favorable outcomes in humans infected with Coronavirus including faster time to recovery and shorter hospital stay.  US CDC research shows that chloroquine also has strong potential as a prophylactic (preventative) measure against coronavirus in the lab, while we wait for a vaccine to be developed.  Chloroquine is an inexpensive, globally available drug that has been in widespread human use since 1945 against malaria, autoimmune and various other conditions.

It concludes:

Chloroquine can both prevent and treat malaria.  Chloroquine can both prevent and treat coronavirus in primate cells (Figure 1 and Figure 2).  According to South Korean and China human treatment guidelines, chloroquine is effective in treating COVID-19.  Given chloroquine’s human safety profile and existence, it can be implemented today in the U.S., Europe and the rest of the world.  Medical doctors may be reluctant to prescribe chloroquine to treat COVID-19 since it is not FDA approved for this use.  The United States of America and other countries should immediately authorize and indemnify medical doctors for prescribing chloroquine to treat COVID-19.  We must explore whether chloroquine can safely serve as a preventative measure prior to infection of COVID-19 to stop further spread of this highly contagious virus.

Here is the second study by Jianjun Gao, Zhenxue Tian, Xu Yang

Abstract:

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future.

Here is the third, in the journal Nature. It’s titled ‘Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro’

Extract:

Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 μM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration.11Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV.

What does this mean?

Essentially it means the end of the nightmare is – or ought to be – much closer than we think.

It will take many, many months before a vaccine is available for COVID-19. In the meantime, this is a very effective stop-gap solution. Not only does it make those critically affected by the virus less likely to die; but it also acts as a prophylactic – that is, it is capable of stopping people from getting the disease in the first place.

The reason that Chloroquine works, I understand from an expert in viral pandemics, is that enables the body to absorb more zinc. Zinc appears to be the most effective agent in disrupting the virus and preventing the ‘cytokine storm’, which is the deadly phase in which the virus tricks the body’s immune system into attacking its own healthy tissue, with often fatal consequences.

Why isn’t there more excitement about this readily available treatment?

One possible reason is that chloroquine is a generic drug to which no pharmaceutical company owns the patent. Big Pharma’s money and lobbying power will strive to persuade governments – and markets – that the only viable solution to the coronavirus is a vaccine. But in the short term this simply isn’t true. Nor is it clear to me that the global economy is going to survive on lockdown for as long as it takes to develop and test that vaccine – which may not even prove effective in any case.

Note that point in the Todaro and Rigano paper about the need for FDA approval. There is no time to waste.

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Halal Bacon
Halal Bacon
4 years ago

mmm, gin and tonic

felix1999
felix1999
4 years ago
Reply to  Halal Bacon

Nah, Long Island Iced Tea.
😉

Achmed Mohandjob
Achmed Mohandjob
4 years ago
Reply to  felix1999

Where’s the quinine in a LIIT?

felix1999
felix1999
4 years ago

I could just use a drink! I wasn’t thinking about quinine. It’s s crazy out there!

I’ve become more of a boring teetotaler. My resistance is low. A couple sips of anything alcoholic would probably put me to sleep. It’s not like my younger days….

Achmed Mohandjob
Achmed Mohandjob
4 years ago
Reply to  felix1999

I know from whence you speak. I used to be able to pound down a fifth of single malt and walk a straight line, heel-toe. An old acquaintance dropped by Tuesday night. I broke out two bottles of a 1979 St. Emilion. Over a three hour period, we polished them off. In the old days, that wouldn’t have even made pre-game warmups. However, I was almost ready to call it a night, at 8:00 pm, EDT. I don’t think that I was walking that well, either.

DemocracyRules
DemocracyRules
4 years ago

Relax, you guys! Hydroxychloroquine is different from quinine, and you would have to drink a gallon of tonic water to get much quinine anyway. Plus, some tonic water is just ‘quinine flavored’, and it costs more than the pills. Also, it was the azithromycin antibiotic added to hydroxychloroquine that did the best.

Achmed Mohandjob
Achmed Mohandjob
4 years ago
Reply to  DemocracyRules

That’s why you buy quinine water, as opposed to tonic. If it worked for the East Indian Trading Company, it’s good enough for me. Gin and quinine, please. I can buy quinine water for under a buck a liter (almost twice the price of tonic water). The gin costs far more than the quinine. Moreover, I don’t need a prescription.

DemocracyRules
DemocracyRules
4 years ago

Ach: Drink all you like! But please, if you get Covid-19, see your doctor. I need to keep you around, in case I want to buy oil wells.

Achmed Mohandjob
Achmed Mohandjob
4 years ago
Reply to  DemocracyRules

Did I cover my West Texas Intermediate WAY too soon? Or, did I cover my West Texas Intermediate way too soon?
Woulda, shoulda, coulda, hadda, oughta, and never short Tandy.

felix1999
felix1999
4 years ago

I will make a note of that. I hate going to doctors for anything.

Achmed Mohandjob
Achmed Mohandjob
4 years ago
Reply to  felix1999

Don’t forget the gin.

felix1999
felix1999
4 years ago
Reply to  DemocracyRules

You seem to well versed on this stuff. I have to learn as I go along on this subject.

Achmed Mohandjob
Achmed Mohandjob
4 years ago
Reply to  Halal Bacon

Quinine has been used for close to 400 years to treat malaria.
However, you’ll find that quinine water has substantially more quinine, in it, that tonic water. An extra wedge of lime is all that it takes to make it palatable.
Gin and quinine, please.

TomSJr
TomSJr
4 years ago

POOR, POOR LIBERALS! They just can’t win AT ANYTHING! HATRED BLINDS THEM TO ANY GOOD AROUND THEM and they MISS it all! I CALL THAT WINNING AGAINST EVIL!

TRUMP/PENCE 2020
WINNING! KAG!
#NODemocrats

felix1999
felix1999
4 years ago
Reply to  TomSJr

Trump may need to adjust his attack on the Chinese virus.

Achmed Mohandjob
Achmed Mohandjob
4 years ago

Hey, if that stuff works, let’s have a shot at quinine, which has been used to treat malaria for close to four hundred years.
What better way to fight the corona beer virus.
Another gin and tonic, please.

AlgorithmicAnalyst
AlgorithmicAnalyst
4 years ago

Hence the reason for tonic water (quinine water).

DemocracyRules
DemocracyRules
4 years ago

Here’s the abstract from the French study tha just came out:
Abstract
Background
Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the role of hydroxychloroquine on respiratory viral loads.
Patients and methods
French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily, and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center, and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.
Results
Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported of untreated patients in the literature. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.
Conclusion
Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.

DemocracyRules
DemocracyRules
4 years ago
Reply to  DemocracyRules

Trump’s team is on it right now, doing a new test to make sure the French study is valid. That will probably take 10 days. But if I was really sick with Covid-19, I would ask a doctor for these meds. They are quite safe and cheap, every pharmacy carries them, and most physicians can prescribe them.

felix1999
felix1999
4 years ago
Reply to  DemocracyRules

Trump is quick. It’s the FDA that drags its feet. I’d bet the FDA is like a country club looking for payoffs to okay drugs. Maybe I have become too cynical.

DemocracyRules
DemocracyRules
4 years ago
Reply to  felix1999

The FDA can be bypassed in this case. These meds are already proven safe and effective for other uses, and approved by the FDA. Most physicians can prescribe existing meds ‘off-label’ for other indications like this one. So docs can be writing scrips right away.

Eventually, the FDA will add Covid-19 to the indications for these meds, if the meds work for Covid-19. And maybe they won’t. The French study was very quick, and had only 20 patients in treatment. Some patients were not helped. Even scientists sometimes get excited and exaggerate.

felix1999
felix1999
4 years ago
Reply to  DemocracyRules

Allot of doctors are reluctant to do that because of liabilty. My old GP would prescribe that but he retired in January. His replacement is one that would be prickily to deal with. I just haven’t gotten around to replacing her. Allot of GP doctors are not taking on new patients…. At the moment I don’t need her….

DemocracyRules
DemocracyRules
4 years ago
Reply to  felix1999

Here’s a link to the actual peer-reviewed published study, in English:
https://drive.google.com/file/d/186Bel9RqfsmEx55FDum4xY_IlWSHnGbj/view
Trump talked about it today. You can download it and/or print it, and have it ready to shove into your doctor’s hands. Docs are used to getting internet stuff from patients, but his one comes from the ‘International Journal of Antimicrobial Agents’, a respected science journal.

felix1999
felix1999
4 years ago
Reply to  DemocracyRules

I’m not sure she’s the type that would like to be informed by a patient….Eventually I will get rid of her. It’s hard finding a good GP.

Mark Steiner
Mark Steiner
4 years ago
Reply to  felix1999

Foot dragging by FDA Deep Stater Dr. Hahn, Big Pharma and the AMA aligned against chloroquine.

Mathew M
Mathew M
4 years ago
Reply to  felix1999

I stand with you on that Felix, I’m still waiting on the FCC to curb the film industry 1950’s would be a good start for rollback. Kids don’t stand a chance today without diligent parenting.

felix1999
felix1999
4 years ago
Reply to  DemocracyRules

Trump is quick. It’s the FDA that drags its feet. I’d bet the FDA is like a country club looking for payoffs to okay drugs. Maybe I have become too cynical.

felix1999
felix1999
4 years ago
Reply to  DemocracyRules

Hopefully the FDA can speed up approval for THIS usage. It’s been approved for OTHER uses but not this USE. Geesh!

If the FDA knew it was used for SARS 1 and effective, why hasn’t it been approved for use in THIS virus, SARS 2? It’s part of the same family.

DemocracyRules
DemocracyRules
4 years ago
Reply to  felix1999

Well the SARS virus is extinct in the wild, it only lives in labs now. So it’s too late to test chloroquine drugs on SARS patients. The chloroquine was only tested in test tubes against SARS, and that’s a long way from real life.

We will see some docs writing scrips for these meds today. It’s horrible to watch patients pass away from severe pneumonia. And anything is worth a try at that point.

felix1999
felix1999
4 years ago
Reply to  DemocracyRules

I just want this nightmare to end!

DemocracyRules
DemocracyRules
4 years ago
Reply to  felix1999

I know, and it will. But we have to let docs do their jobs. Don’t worry about the liability, Trump helped pass “right to try” legislation, and there are other compassionate means for patients to insist on experimental treatments.

DemocracyRules
DemocracyRules
4 years ago
Reply to  DemocracyRules

So THAT’S where all that toilet paper went: “Early symptom of coronavirus might be digestive issues”
https://www.foxnews.com/health/early-symptom-coronavirus-might-be-digestive-issues-study

sumsrent
sumsrent
4 years ago
Reply to  felix1999

I agree… I”m losing way too much money over this garbage…

Dorrie - Conservative
Dorrie - Conservative
4 years ago
Reply to  DemocracyRules

I thank GOD this is not a Democracy! It is a CONSTITUTIONAL REPUBLIC, NOT a Democracy!!

DemocracyRules
DemocracyRules
4 years ago

Hey Dorrie!

Mark Steiner
Mark Steiner
4 years ago

Dr. Hahn of the FDA was not very enthusiastic about use of chloroquine for Corona. Examine his dour face during Thursday’s conference with the President. His response confirms he is a Deep State punk, and in with the perverts of Big Pharma and the AMA.

To make progress combating the virus, his type must go.

felix1999
felix1999
4 years ago

Note that point in the Todaro and Rigano paper about the need for FDA approval. There is no time to waste.

The FDA favors pharms.. If a pharm didn’t patent it, why would the FDA want it approved? It’s all about money and how each can benefit from it. Hopefully Trump can do something about this.

felix1999
felix1999
4 years ago

Can you use that for preventive care without side effects?

DemocracyRules
DemocracyRules
4 years ago
Reply to  felix1999

South Korea is still looking good…comment image

DemocracyRules
DemocracyRules
4 years ago
Reply to  DemocracyRules

Israel just went on lock down today
Too funny, at presser today:
Trump To Liberal Reporters: “We Should Get Rid Of 80% Of You”

Dan Knight
Dan Knight
4 years ago
Reply to  DemocracyRules

I heard that … it was great. 😉

you and yours have a wonderful week, DR!

DemocracyRules
DemocracyRules
4 years ago
Reply to  Dan Knight

Thanks Dan, You too!

felix1999
felix1999
4 years ago
Reply to  felix1999

Unfortunatley with allot of incompetent doctors out there shuffled through medical school based on identity politics, a patient is forced to do their own research. Dosage will probably be influenced by weight and over all health. We are used to doing our own reasearch.

sumsrent
sumsrent
4 years ago

Good article… we have hope… 🙂

[edit] Of course… the massive lying idiot Trumpo is still an idiot…

Halal Bacon
Halal Bacon
4 years ago

bingo!

Zinc Deficiency
Zinc deficiency is characterized by growth retardation, loss of appetite, and impaired immune function

https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

knightsstrength
knightsstrength
4 years ago

Let’s hope we have a cure but keep up with the other tests

stephen5970
stephen5970
4 years ago

Go to doctor. Tell doctor that you have come down with malaria (wink wink). Ask for the treatment and an antibiotic.

Who knows, it might work.

felix1999
felix1999
4 years ago
Reply to  stephen5970

They may want to test you for it unless you have a flexible doctor.

Dan Knight
Dan Knight
4 years ago

Great news …

Efficacy is always a tricky subject … i.e. what does it really do? When does it do it? Who is it good for? When should it be used? … etc. … I’m sure it’s not as simple as a ‘magic bullet’ … but if it helps … Hoorah!

Also … we hope for a vaccine … we don’t plan on a vaccine.

Vaccines can be tricky too.

sumsrent
sumsrent
4 years ago

Chris Martenson reported on this over a month ago…

For the best info on CV19… everyday…

You Tube… “Peak Prosperity”…

1PierreMontagne1
1PierreMontagne1
4 years ago

The Leftist Liberals will be outraged – all the hope for civil war to avoid a Trump re-election is now dashed.
The MSM will claim the whole pandemic thing was a false flag designed to make Trump Look good.
Biden will be happy he wont have to be President after all.

John Acord
John Acord
4 years ago

This medicine should be approved for OTC use immediately. There will be a hundred OTC manufacturers rushing to fill the shelves.

CARRENO BARTOX
CARRENO BARTOX
4 years ago

Dearest Pamela !

Billions of Influenza patients and ten thousands of COVID19 patients have been treated with medications which are suppressing their vital immune systems, medicaments which can be bought over the counter !!!

Here the most popular medicaments for treating Influenza which are widely used also by patients suffering of COVID19:
ACETAMINOPHEN (PARACETAMOL), ISOBUTYLPHENYLPROPIONIC ACID (IBUPROFEN), METAMIZOL-SODIUM (NOVALGIN, banned in US), and their “relatives” / derivatives.

And what for ?
Mostly to lower pain and fever which come with influenza and COVID19 – right ?
Sure – fever & pain make us feeling sometimes very uncomfortable and bad – BUT to lower fever and pain, which in unnumbered cases could be supported and treated otherwise without drugs … is it worth to WEAKEN our immune system, which is the ONLY OPTION to kill the viruses, especially in elder people cases ?!

NOBODY KNOWS how many patients passed “more comfortably” away because of taking these medicaments which have influenced their immune system negatively.

Don’t let us forget how wicked and selfish a lot of pharmaceutical companies were and are acting, and how much money is made by them and the pharmacies, with medicaments which are sometimes dubious and dangerous.

Do not forget :
Pharmacists basically do not study medicine, do not examine patients, cannot judge the level of illness, are not entitled to recommend medicaments whithout a proper diagnosis, and therefore are NOT Medical Doctors.
Be sure – the producers and their lobbyists won’t let pass the opportunity to make BIG money during the COVID19 pandemic…

By the way – the active ingredients of ACETAMINOPHEN (PARACETAMOL, TYLENOL), ISOBUTYLPHENYLPROPIONIC ACID (IBUPROFEN), are mostly produced in ASIA, and are unbelievable cheap – BILLIONS are made by selling them…

Last not least : NOTHING is proved regarding “CHLOROQUIN” – the study which is made in FRANCE is absolutely dubious, has no relevance for the human body.
NOBODY could pretend to know if CHLOROQUIN is a useful or a possibly dangerous treatment against Influenza and COVID19 !

sumsrent
sumsrent
4 years ago

TDS = Trumpo Derangement Syndrome…

These people worship the idiot Trumpo… they believe he is a god…

They are mesmerized by every word the massive lying idiot Trumpo speaks…

They are incapable of deciphering the idiot Trumpo’s lies…

williamdiamon
williamdiamon
4 years ago
Reply to  sumsrent

comment image

DVader
DVader
4 years ago

The head of the FDA backpedaled immediately, saying testing had only started and has a long way to go.
Obviously you automatically believe anything Trump says. What you automatically need to do is to do a sanity check on anything Trump says.

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